The results of the various studies conducted at the LaRCAO have been published in peer-reviewed ophthalmology journals.


Publications from the Thessaloniki Eye Study so far include the following:

1.       Topouzis F.,Wilson M.R., Harris A., Founti  P., Yu F., Anastasopoulos E.,  Pappas T.,  Koskosas A., Salonikiou A., Coleman A.L. Risk factors for primary open-angle glaucoma and pseudoexfoliative glaucoma in the Thessaloniki Eye Study. Am J Ophthalmol. 2011;152:219-228

2.       Anastasopoulos E, Topouzis F, Wilson MR, Harris A, Theofanis P, Yu F, Koskosas A, Founti P, Coleman AL. Characteristics of Pseudoexfoliation in the Thessaloniki Eye Study. J Glaucoma. 2011;20:160-6.

3.       Topouzis F, Harris A, Wilson MR, Koskosas A, Founti P, Yu F, Anastasopoulos E, Pappas T, Coleman AL. Increased likelihood of glaucoma at the same screening intraocular pressure in subjects with pseudoexfoliation: the Thessaloniki Eye Study. Am J Ophthalmol. 2009;148:606-613

4.       Topouzis F, Coleman AL, Harris A, Koskosas A, Founti P, Gong G, Yu F, Anastasopoulos E, Pappas Th, Wilson MR. Factors associated with undiagnosed Open Angle Glaucoma. The Thessaloniki Eye Study. Am J Ophthalmol 2008;145:327-35.

5.       Topouzis F, Wilson M.R., Harris A, Anastasopoulos E, Yu F, Mavroudis L, Pappas Th, Koskosas A, Coleman A.L. Prevalence of Open Angle Glaucoma in Greece. The Thessaloniki Eye Study. Am J Ophthalmol 2007;144:511-19.

6.       Mavroudis L, Harris A, Topouzis F, Wilson MR, Yu F, Anastasopoulos E, Koskosas A, Siesky B, Pappas T, Founti P, Coleman AL. Reproducibility of pixel-by-pixel analysis of Heidelberg Retinal Flowmetry (HRF) images: The Thessaloniki Eye Study. Acta Ophthalmologica 2008;86:81-6.

7.    Topouzis F, Coleman AL, Harris A, Anastasopoulos E, Yu F, Koskosas A, Pappas T, Mavroudis L, Wilson MR. Prevalence of age-related macular degeneration in Greece. The Thessaloniki Eye Study. Am J Ophthalmol, 2006;142:1076-9.

8.      Topouzis F, Coleman AL, Harris A, Jonescu-Cuypers C, Yu F, Mavroudis L, Anastasopoulos E, Pappas T, Koskosas A, Wilson MR. Association of blood pressure status with the optic disc structure in non glaucoma subjects. The Thessaloniki Eye Study.  Am J Ophthalmol 2006;142:60-7.

9.   Topouzis F, Coleman AL, Yu F, Mavroudis L, Anastasopoulos E, Koskosas A, Pappas Th, Dimitrakos S, Wilson MR. Sensitivity and specificity of the 76-Suprathreshold visual field test to detect eyes with visual field defect by Humphrey threshold testing in a population-based setting. The Thessaloniki Eye Study. Am J Ophthalmol. 2004; 137: 420-5.


Publications from the Eureye Study so far include the following:


1.       Walsh S, Wollstein A, Liu F, Chakravarthy U, Rahu M, Seland JH, Soubrane G, Tomazzoli L, Topouzis F, Vingerling JR, Vioque J, Fletcher AE, Ballantyne KN, Kayser M. DNA-based eye colour prediction across Europe with the IrisPlex system. Forensic Sci Int Genet. 2011 Aug 1. [Epub ahead of print]

2.    McKay GJ, Patterson CC, Chakravarthy U, Dasari S, Klaver CC, Vingerling JR, Ho L, de Jong PT, Fletcher AE, Young IS, Seland JH, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Hingorani AD, Sofat R, Dean M, Sawitzke J, Seddon JM, Peter I, Webster AR, Moore AT, Yates JR, Cipriani V, Fritsche LG, Weber BH, Keilhauer CN, Lotery AJ, Ennis S, Klein ML, Francis PJ, Stambolian D, Orlin A, Gorin MB, Weeks DE, Kuo CL, Swaroop A, Othman M, Kanda A, Chen W, Abecasis GR, Wright AF, Hayward C, Baird PN, Guymer RH, Attia J, Thakkinstian A, Silvestri G. Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies. Hum Mutat. 2011 Aug 31. doi: 10.1002/humu.21577. [Epub ahead of print]

3.   Seland JH, Vingerling JR, Augood CA, Bentham G, Chakravarthy U, Dejong PT, Rahu M, Soubrane G, Tomazzoli L, Topouzis F, Fletcher AE. Visual Impairment and quality of life in the Older European Population, the EUREYE study. Acta Ophthalmol. 2011;89:608-613.

4.       Mckay G., Silvestri G., Chakravarthy U., Dasari S., Fritsche L.G., Weber B.H., Keilhauer C.N., Klein M.L., Francis P.J., Klaver C.C., Vingerling J.R., Ho L., De Jong P.T.D.V.., Dean M., Sawitzke J., Baird P.N., Guymer R.H., Stambolian D.G., Orlin A., Seddon J.M., Peter I., Wright A.F., Hayward C., Lotery A.J., Ennis S., Gorin M.B., Weeks D.E., Kuo G., Hingorani A.D., Sofat R., Cipriani V., Swaroop A., Othman M., Kanda A., Chen W., Abecasis C.R., Yates J.R., Webster A.R., Moore A.T., Seland J., Rahu M., Soubrane G., Tomazzoli L., Topouzis F., Vioque J and Fletcher A. ,  The Rotterdam Study Group, The Eureye Study group and Patterson C.C. Variations with age in Apolipoprotein E frequency in a pooled analysis of a large group of older people. Am J Epidemiol. 2011;173:1357-64. Review.

5.       Topouzis F, Anastasopoulos E, Augood C, Bentham GC, Chakravarthy U, de Jong PT, Rahu M, Seland J, Soubrane G, Tomazzoli L, Vingerling JR, Vioque J, Young IS, Fletcher AE. Association of diabetes with age-related macular degeneration in the EUREYE study. Br J Ophthalmol. 2009;93:1037-41.

6.       Fletcher AE, Bentham GC, Agnew M, Young IS, Augood C, Chakravarthy U, de Jong PT, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vingerling JR, Vioque J. Sunlight exposure, antioxidants, and age-related macular degeneration. Arch Ophthalmol. 2008;126:1396-403.

7.       Augood C, Chakravarthy U, Young I, Vioque J, de Jong PT, Bentham G, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vingerling JR, Fletcher AE. Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration. Am J Clin Nutr. 2008;88:398-406.

8.       Chakravarthy U, Augood C, Bentham G, deJong PTVM, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Fletcher A. Cigarette smoking and age-related macular degeneration in the Eureye Study.  Ophthalmology 2007;114:1157-63.

9.       Augood CA, Vingerling JR, de Jong PT, Chakravarthy U, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Bentham G, Rahu M, Vioque IS, Fletcher AE. Prevalence of age-related maculopathy in older Europeans: the European Eye Study (EUREYE). Arch Ophthalmol. 2006;124:529-35.

10.   Augood C, Fletcher A, Bentham G, Chakravarthy U, de Jong PTVM, Rahu M, Seland J, Soubrane G, Tomazzoli L, Topouzis F, Vioque J, Young I. Methods for a population-based study of the Prevalence And Risk Factors For Age-Related Maculopathy and Macular Degeneration In Elderly European Populations: the EUREYE Study. Ophthalmic Epidemiol. 2004; 11: 117-29.


Other publications:

1.       Kilintzis V, Pappas T, Chouvarda I, Salonikiou A, Maglaveras N, Dimitrakos S, Topouzis F. Novel Heidelberg Retina Tomograph based Morphological Parameters derived from optic disc cupping surface processing Invest Ophthalmol Vis Sci. 2011 Feb 16;52(2):947-51.

2.       Mataftsi A., Fragkou A., Vezyri E., Topouzis F., Diza E., Dimitrakos S.A., Unusual toxoplasmic chorioretinitis in advanced age: a diagnostic problem. Semin Ophthalmol. 2011 Jan;26(1):4-6.

3.       Reus NJ, Lemij HG, Garway-Heath DF, Airaksinen PJ, Anton A, Bron AM, Faschinger C, Holló G, Iester M, Jonas JB, Mistlberger A, Topouzis F, Zeyen TG. Clinical Assessment of Stereoscopic Optic Disc Photographs for Glaucoma: The European Optic Disc Assessment Trial. Ophthalmology. 2010 Apr;117(4):717-23.

4.       Altsitsiadis E., Hinrichs B., Topouzis F., Stockfleth E., Pappas K. Decision Support Systems in Health Care: towards a Simulated Health System. European Journal of ePractice Dec. 2009;1988-625X.

5.       Topouzis F, Founti P. Weighing in ocular perfusion pressure in managing glaucoma. Open Ophthalmol J. 2009;3:43-5.

6.       Topouzis F, Anastasopoulos E. Incidence of pseudoexfoliation syndrome. Am J Ophthalmol. 2009;148:181-2

7.       Appropriateness of Treating Glaucoma Suspects RAND Study Group. For which glaucoma suspects is it appropriate to initiate treatment? Ophthalmology. 2009;116:710-6, 716

8.       Founti P, Topouzis F, van Koolwijk L, Traverso CE, Pfeiffer N, Viswanathan AC. Biobanks and the importance of detailed phenotyping: a case study--the European Glaucoma Society GlaucoGENE project. Br J Ophthalmol. 2009;93:577-81

9.       Coleman AL, Stone KL, Kodjebacheva G, Yu F, Pedula KL, Ensrud KE, Cauley JA, Hochberg MC, Topouzis F, Badala F, Mangione CM; Study of Osteoporotic Fractures Research Group. Glaucoma risk and the consumption of fruits and vegetables among older women in the study of osteoporotic fractures. Am J Ophthalmol. 2008;145:1081-9.

10.   Topouzis F, Koskosas A, Pappas T, Anastasopoulos E, Raptou A, Psilas K. Foveomacular retinitis and associated optical coherence tomography findings. Ophthalmic Surg Lasers Imaging. 2007;38:333-5.

11.   Topouzis F. Is microdensitometric method a new gold standard for retinal arteriolar narrowing detection?” Am J Hypertens 2007;20:506-7.

12.   Rossetti L, Karabatsas CH, Topouzis F, Vetrugno M, Centofanti M, Boehm A, Viswanathan A, Vorwerk C, Goldblum D. Comparison of the effects of Bimatoprost and a fixed combination of Latanoprost and Timolol on Circadian intraocular pressure. Ophthalmology 2007;114:2244-51.

13.   Topouzis F, Melamed S, Danesh-Meyer H, Wells AP, Kozobolis V, Wieland H, Andrew R, Wells D. and the International Travoprost/Timolol study group. "A One-year Study to Compare the Efficacy and Safety of Once-Daily Travoprost 0.004%/Timolol 0.5% to Once-Daily Latanoprost 0.005%/Timolol 0.5% in Patients with Open-Angle Glaucoma or Ocular Hypertension". Eur J Ophthalmol 2007;17:183-90.

14.   Boura P, Tselios K, Kamali S, Skendros P, Sarantopoulos A, Topouzis F. Concurrent relapsing central nervous system and ocular involvement in a case of life-threatening Adamantiades-Behcet Disease (ABD). Neurol Sci. 2006;27:432-5.

15.   Konstas AG, Topouzis F, Leliopoulou O, Pappas T, Georgiadis N, Jenkins JN, Stewart WC. 24-hour intraocular pressure control with maximum medical therapy compared with surgery in patients with advanced open-angle glaucoma. Ophthalmology. 2006;113:761-5.

16.   Tsina Ef, Udar N, Small K, Topouzis F. An atypical presentation of lattice corneal dystrophy in a patient with juvenile glaucoma. EYE. 2006;20:979-80.

17.   Topouzis F, Tranos P, Koskosas A, Pappas T, Anastasopoulos E, Dimitrakos S, Wilson MR. Risk of sudden visual loss following filtration surgery in end-stage glaucoma. Am J Ophthalmol 2005;140:661-6.

18.   Jonescu-Cuypers CP, Harris A, Wilson R, Kagemann L, Mavroudis LV, Topouzis F, Coleman AL. Reproducibility of the Heidelberg Retinal Flowmeter in determining low perfusion areas in peripapillary retina. Br J Ophthalmol. 2004; 88: 1266-9.

19.   Tranos PG, Topouzis F, Stangos NT, Dimitrakos S, Economidis E, Harris M, Coleman AL. Effect of laser photocoagulation treatment for diabetic macular edema on patient’s vision-related quality of life. Curr Eye Res. 2004; 29: 41-9.

20.   Tranos P, Wickremasinghe S, Stangos N, Topouzis F, Tsinopoulos I, Pavesio C.  Macular edema. Surv Ophthalmol. Major review. 2004; 49: 470-90.

21.   Tsinopoulos I, Tranos P, Topouzis F, Hundal K, Brazitikos F.  Atypical Acute Retinal Necrosis (ARN) responding to late treatment. EYE. 2004; 18: 203; discussion 203-4.

22.   Konstas AG, Stewart WC, Topouzis F, Tersis I, Holmes KT, Stangos NT.  Brimonidine 0.2% given two or three times daily versus timolol maleate 0.5% in primary open-angle glaucoma. Am J Ophthalmol 2001; 131:729-733.

23.   Karadimas P, Bouzas EA, Topouzis F, Vouza A, Koutras DA, Mastorakos G. Hypothyroidism and glaucoma. Am J Ophthalmol. 2001;131:126-8.